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Disruption of GPX4 in a human carcinoma cell line can up-regulate the expression of 12-lipoxygenase and cyclooxygenase 1 (COX1) that triggers inflammatory responses [55, 56]

In essence, the enzyme serves to transfer electrons from NAD(P)H to ground state oxygen to create O 2 - that then dismutates to H 2 O 2 under the influence of intracellular superoxide dismutase (Fig

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Therefore, for this comparison we used the SHuffle progenitor strain MB1731 to express all cyclonal constructs, because it has an oxidizing cytoplasm but lacks a cytoplasmic copy of dsbC

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This is not a contraindication to treatmentit is a reason for more intentional oversight and potential dose adjustment